7:30 am Morning Refreshments & Check In
8:25 am Chair’s Opening Remarks
UTILIZING PERSONALISED MEDICINE & PATIENT CENTRIC APPROCAHES TO DEVELOP NOVEL REGULATORY DECISION-ENABLING ENDPOINTS ACROSS VARIOUS RETINAL DISEASES
8:30 am Developing Novel Clinical Endpoints to Improve Clinical Trials Design & Population Enrichment for Retinal Disease & Pipeline Development
Synopsis
- Uncovering novel clinical trial endpoints for Dry AMD, Wet AMD and other retinal vascular diseases
- Reviewing the journey of emerging GA endpoints from being non-measurable to achieving FDA approval
- Utilizing biomarkers for clinical trial enrichment to allow for more efficient clinical trial execution
- Integration of AI into imaging biomarker exploration, as an additional tool to human data analyses expertise
9:00 am Imaging the Ellipsoid Zone as a Biomarker for Clinical Trials for Inherited Retinal Diseases
Synopsis
- Ellipsoid zone as a tool to monitor disease progression and patient selection in clinical trials
- Reviewing OCT biomarkers and adaptive optics and their applications to clinical trials
- Sharing Phase 1/2 clinical trial data
9:30 am Implementing Functional Retinal Testing in Geographic Atrophy Clinical Trials
Synopsis
- Understanding the structure-function relationship in Geographic Atrophy to develop new imaging endpoints for use in clinical trials
- Utilizing different testing strategies with Microperimetry to study the response to therapies currently being developed for dry AMD
- Reviewing Microperimetry data from clinical trials in Geographic Atrophy
10:00 am Speed Networking
Synopsis
An optimal chance to network one-to-one with leading retinal imaging experts working across various retinal indications. Learn how your peers are developing novel imaging technology to reduce timelines, optimize patient detection and selection, and discuss the future of retinal imaging.
10:45 am Morning Refreshments Break
ASSESSING & NAVIGATING THE TRANSLATABILITY OF DATA WHEN USING CLINICAL IMAGING DEVICES IN PRECLINICAL MODELS
11:30 am Leveraging Ex Vivo Retinal Imaging Technology to Establish Functional Drug Efficacy Endpoints
Synopsis
- Developing novel preclinical tools for accelerating drug discovery
- Optophysiology vs Electrophysiology: Reviewing unique ways of imaging the retina at a cellular resolution
- Functional classification or retinal ganglion cells as a measure of glaucoma model progression
12:00 pm Session Reserved for iCare
12:10 pm Multimodal Imaging Methods to Assess Ocular Distribution of Suprachoroidally Administered Therapeutics for Chorioretinal Diseases
Synopsis
- Discussing various imaging techniques, such as OCT-A, SLO, colour fundus photography and retinal flatmount, their applications, limitations, and future potentials
- Assessing posterior, circumferential, and macular spread of injectate using multimodal imaging
- Evaluating translatability of preclinical ex vivo and in vivo assessment to clinics
12:40 pm Lunch & Networking Break
2:10 pm Session Reserved for Translational Imaging Innovations
2:20 pm In Vivo Quantification of Retinal Vascular Leakage in Diabetic Retinopathy & Wet AMD Mouse Models
Synopsis
- Understanding the requirements from in vivo models with induced retinal vascular leakage to better show drug efficacy in the preclinical stage for improved translatability in humans
- Improving models for geographic atrophy for earlier disease detection and treatment intervention
- Developing disease-specific preclinical models of macular degeneration, with human phenotypes, to achieve desired outcomes for easier translation into humans
- Exploring adaptive optics technology for in vivo examination of the individual photoreceptors and retinal vasculature to better understand retinal pathologies
DEVELOPING SENSITIVE & SPECIFIC NOVEL RETINAL IMAGING DEVICES TO MONITOR REAL-TIME ANALYSIS & DISEASE PROGRESSION
2:50 pm Developing Sensitive & Specific Novel Retinal Imaging Devices to Image Disease Progression in Clinical Trials
Synopsis
- Developing new imaging tools with high resolution and high contrast images with minimal scatter in the field of view
- Understand the possibility of live imaging in the retina to monitor diseases progression in real time and measure drug efficacy
- Early detection and diagnosis of patients via imaging
3:20 pm Exploring the Use of Serial Coronary CT Imaging to Detect Atherosclerosis Progression: Lessons From the High-Risk Coronary Plaque
Synopsis
- Demonstrate how coronary CT imaging provides a reliable biomarker to detect lipid rich necrotic core (akin to geographic atrophy in the eye)
- Understand how serial image tracking reduces future heart attack risk (akin to major vision loss in GA)
- Showcase how current efforts in cardiovascular drug development have provided accepted paths to obtain FDA approval for emerging therapies (akin to EZ imaging in the eye)
COMPARE & CONTRAST RETINAL IMAGING TOOLS FOR VARIOUS RETINAL DISORDERS INCLUDING WET AMD, DIABETIC EYE DISEASES, DRY AMD, GEOGRAPHIC ATROPHY, INHERITED RETINAL DISEASES & GLAUCOMA
4:10 pm Afternoon Networking Break
4:40 pm Roundtable Discussion
Synopsis
- Understanding the Relationship between the various retinal imaging biomarkers with disease progression
- Challenges associated with the interpretation of imaging data – do they demonstrate drug safety and efficacy?
- How can AI be used to further refine knowledge from retinal imaging? Discussing the role of AI in drug target identification, safety and efficacy assessment
Moderator Feedback & Audience Debate:
Moderators will be assigned to each roundtable to facilitate discussion and collate the findings. Following the roundtable discussions, they will present back to the entire delegation and open up wider audience debate.
5:40 pm Chair’s Closing Remarks
5:45 pm Scientific Poster Session
Synopsis
Aside from the formal presentations, the sharing and learning doesn’t stop as the Scientific Poster Session takes place. This will serve as the perfect opportunity to share your recent work developing novel retinal imaging modalities with the community.