7:50 am Registration & Morning Coffee
8:50 am Chair’s Opening Remarks
REINVENTING REGULATORY ENDPOINTS TO ACHIEVE VALIDATION & APPROVAL OF SOPHISTICATED RETINAL IMAGING TECHNOLOGIES
9:00 am Panel Discussion: Developing Clinical Endpoints Based on Current Standards of Approval & Steering Guidance for Future Investment
Synopsis
- Evaluating the current regulatory standpoint for retinal imaging technologies and the type of data required to be generated
- Determining how regulatory guidance is looking to evolve to inform future pipeline decisions
- Deciphering how structural endpoints correlate to function in different retinal conditions
9:30 am Evaluating the Potential of New Endpoints Derived From Advanced Imaging Technologies
Synopsis
- Harnessing newer imaging modalities to provide indicators of therapeutic effect required for clinical progression
- Evaluating possible new endpoints in the retina based on current assessments of retinal disease pathologies
- Exploring how advancing knowledge in retinal disorders can be translated into novel endpoints that meet validation standards
10:00 am Roundtable Discussion
Synopsis
This session is designed to allow all attendees to contribute to discussion on the field’s most pressing challenges to gather key takeaways and learnings from peers. Attendees will be divided into three roundtables, each with an assigned topic to be evaluated:
- Preclinical Imaging Roundtable
- Clinical Imaging Roundtable
- AI Screening Roundtable
10:30 am Morning Break & Refreshments
EXPLORING ADDITIONAL METHODS TO OPTIMIZE IMAGE-DERIVED DATA & ENHANCE RETINA VISUALIZATION
11:30 am Unlocking the Potentials of Adaptive Optics to Elevate Resolution at the Cellular Level
Synopsis
- Determining how increased resolution translates into a greater usefulness in clinical trials
- Comparing the advantages and limitations of adaptive optics retinal imaging as a tool to facilitate visualization of retinal diseases
- Exploring adaptive optics retinal imaging biomarkers relevant to disease and treatment outcomes
12:00 pm Harnessing Ultrawidefield Imaging Endpoints & Biomarkers
Synopsis
- Accessing both posterior and peripheral visualization of the retina to better predict likelihood of disease progression
- Enhancing visualization capabilities with ultra-widefield imaging to more easily capture the entire retina
- Detecting retinal neovascularization and lesion distribution with ultra-widefield technology
12:30 pm Exploring the Challenges & Opportunities of 2-Photon Adaptive Optics Imaging
Synopsis
- Evaluating the implementation criteria for 2PSLO (two-photon scanning light ophthalmoscope) to optimize their use in the clinic
- Reviewing the practicalities of 2PSLO
- Assessing the usefulness of 2PSLO-derived biomarkers in a clinical setting
1:00 pm Lunch & Networking Break
REVIEWING PRECLINICAL RETINAL IMAGING STRATEGIES TO ENHANCE TRANSLATIONAL CAPABILITIES
2:00 pm Navigating the Challenges of Developing Imaging Biomarkers of Retinal Disorders in Rodents
Synopsis
- Optimizing light induced retinal injury model development in rats and mice
- Developing a retinal auto segmentation software to enhance preclinical findings
- Identifying translatable retinal biomarkers in a rodent neurodegenerative disease model
2:30 pm Translating Cellular & Molecular Imaging Approaches for Retinal Disease Biomarker & Drug Development
Synopsis
- Optimizing cellular and molecular imaging targets for facilitating translation of retinal therapeutics
- Uncovering advances in cellular and molecular imaging probes for retinal disease
- Progressing translation of preclinical imaging approaches toward clinical applications
3:00 pm A Preclinical Perspective on Efficiently Aligning the Translational Pipeline from Preclinical to Clinical
Synopsis
- Establishing meaningful clinical endpoints early in development to assist in preclinical planning
- Assessing the translatability of preclinical imaging biomarkers and their relative value in decision making
3:30 pm Chair’s Closing Remarks & End of Conference
